Personalized Regenerative Rehabilitation of Osteoarthritis Based on Mechanical Loading and Mechanoregulation
DOI:
https://doi.org/10.31181/smeor21202540Keywords:
Cartilage, Mechan transduction, Stem cells, Scaffolds, Robotic assistanceAbstract
Osteoarthritis is one of the most important “civilizational diseases" that significantly restricts quality of life and active life expectancy. The current practice of treating patients with osteoarthritis often consists in replacing damaged natural joints with artificial ones. Even if the replacement procedure is successful, various complications may occur in the post operation period causing health problems in the long term. The purpose of the current research is to develop methods of regenerative rehabilitation of joints on the basis of personalized treatment technologies of osteoarthritis. This goal can be achieved through the development of programmed mechanical loading of joints taking into account modern knowledge about mechanoregulation of cells, as well as applications of tissue-engineered structures using induced pluripotent stem cells. Local regeneration processes can be supported by targeted delivery of microcapsules of multicomponent lubricants, as well as drugs.
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Cui, A., Li, H., Wang, D., Zhong, J., Chen, Y., & Lu, H. (2020). Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine, 29-30, 100587. https://doi.org/10.1016/j.eclinm.2020.100587
Statista. (2024). Häufigkeit ausgewählter Krankheiten bei Erwerbstätigen in Deutschland nach Altersgruppen im Jahr 2009 [Graph]. Statista. https://de.statista.com/statistik/daten/studie/191728/umfrage/haeufigkeit-ausgewaehlter-krankheiten-bei-erwerbstaetigen-nach-alter/
Popov, V. L., Poliakov, A. M., & Pakhaliuk, V. I. (2021). Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty. Lubricants, 9(2), 15. https://doi.org/10.3390/lubricants9020015
Klein, J. (2006). Molecular mechanisms of synovial joint lubrication. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 220(8), 691-710. https://doi.org/10.1243/13506501JET143
Leroy, J.-E., & Popov, V. L. (2025). Boundary Element Simulation of the Normal Contact Problem with a Poroelastic Half-Space. ZAMM‐Journal of Applied Mathematics and Mechanics/Zeitschrift für Angewandte Mathematik und Mechanik, 105(1).
Chang, S. H., Mori, D., Kobayashi, H., Mori, Y., Nakamoto, H., Okada, K., Taniguchi, Y., Sugita, S., Yano, F., Chung, U.-I., Kim-Kaneyama, J.-R., Yanagita, M., Economides, A., Canalis, E., Chen, D., Tanaka, S., & Saito, T. (2019). Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway. Nature Communications, 10, 1442. https://doi.org/10.1038/s41467-019-09491-5
Zhang, R.-K., Li, G.-W., Zeng, C., Lin, C.-X., Huang, L.-S., Huang, G.-X., Zhao, C., Feng, S.-Y., & Fang, H. (2018). Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1). Bone & Joint Research, 7(11), 587–594. https://doi.org/10.1302/2046-3758.711.BJR-2018-0057.R1
Sun, Y., Chen, C. S., & Fu, J. (2012). Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment. Annual Review of Biophysics, 41, 519–542. https://doi.org/10.1146/annurev-biophys-042910-155306
Elder, B. D., & Athanasiou, K. A. (2009). Hydrostatic pressure in articular cartilage tissue engineering: From chondrocytes to tissue regeneration. Tissue Engineering Part B: Reviews, 15(1), 43–53. https://doi.org/10.1089/ten.teb.2008.0435
Grad, S., Eglin, D., Alini, M., & Stoddart, M. J. (2011). Physical stimulation of chondrogenic cells in vitro: A review. Clinical Orthopaedics and Related Research, 469(10), 2764–2772. https://doi.org/10.1007/s11999-011-1819-9
Poliakov, A., & Pakhaliuk, V. (2023). In silico analysis of an articular cartilage regenerative rehabilitation under conditions of mesenchymal cells implantation and their mechanical stimulation. Facta Universitatis, Series: Mechanical Engineering, 22(3), 399-422. https://doi.org/10.22190/FUME230919051P
Popov, V. L., Poliakov, A. M., & Pakhaliuk, V. I. (2023). In silico evaluation of the mechanical stimulation effect on the regenerative rehabilitation for the articular cartilage local defects. Frontiers in Medicine, 10, 1134786. https://doi.org/10.3389/fmed.2023.1134786
Zheng, W., Li, X., Liu, D., Li, J., Yang, S., Gao, Z., Wang, Z., Yokota, H., & Zhang, P. (2019). Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy. The FASEB Journal, 33(3), 4077–4088. https://doi.org/10.1096/fj.201801851R
Guilak, F., Nims, R. J., Dicks, A., Wu, C. L., & Meulenbelt, I. (2018). Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biology, 71-72, 40–50. https://doi.org/10.1016/j.matbio.2018.05.008
Choi, J. R., Yong, K. W., & Choi, J. Y. (2018). Effects of mechanical loading on human mesenchymal stem cells for cartilage tissue engineering. Journal of Cellular Physiology, 233(3), 1913–1928. https://doi.org/10.1002/jcp.26018
Wyse Jackson, T., Michel, J., Lwin, P., Fortier, L. A., Das, M., Bonassar, L. J., & Cohen, I. (2022). Structural origins of cartilage shear mechanics. Science Advances, 8(6), eabk2805. https://doi.org/10.1126/sciadv.abk2805
Krych, A. J., Harnly, H. W., Rodeo, S. A., & Williams, R. J., 3rd. (2012). Activity levels are higher after osteochondral autograft transfer mosaicplasty than after microfracture for articular cartilage defects of the knee: A retrospective comparative study. The Journal of Bone and Joint Surgery. American Volume, 94(11), 971–978. https://doi.org/10.2106/JBJS.K.00815
Wescoe, K. E., Schugar, R. C., Chu, C. R., & Deasy, B. M. (2008). The role of the biochemical and biophysical environment in chondrogenic stem cell differentiation assays and cartilage tissue engineering. Cell Biochemistry and Biophysics, 52(2), 85–102. https://doi.org/10.1007/s12013-008-9029-0
Tsiapalis, D., & O'Driscoll, L. (2020). Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications. Cells, 9(4), 991. https://doi.org/10.3390/cells9040991
Ji, X., & Zhang, H. (2019). Current Strategies for the Treatment of Early-Stage Osteoarthritis. Frontiers in Mechanical Engineering, 5, 57. https://doi.org/10.3389/fmech.2019.00057
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